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Thyroxine-binding prealbumin. Conformation in aqueous solutions 总被引:3,自引:0,他引:3
D P Hanlon L De Vore M C Kincaid A Jones L Lane 《The Journal of biological chemistry》1971,246(19):6011-6018
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Introduced rat species have been implicated in the decline and local extirpation of numerous seabird species from islands across the globe, leading to widespread eradications as a conservation tool. However, little conclusive evidence has been established to determine the direct mechanisms in which rat and seabird species interact. This study aimed to quantify rates of egg predation by brown rats Rattus norvegicus using automated trail cameras at seabird nests baited with domestic quail and hen eggs to represent different-sized seabird eggs. The trail cameras were in situ for a total of 915 days during June and July 2011. Evidence for rats visiting the experimental nests was only observed at one location, where 19 visits were recorded, and no evidence of rat predation on hen or quail eggs was observed. Low levels of rat activity were observed during the study; therefore, it is not possible to conclude that rats never predate seabird eggs as predation may be more likely when rat densities are higher and pressure on food resources greater. This study does however highlight that where rats occur at low densities, predation of eggs is unlikely. Measures aimed at maintaining low abundance of rats in and around vulnerable seabird colonies may therefore be useful where complete eradication is not feasible, although potential for predation of chicks should also be considered. 相似文献
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Haffner CD Diaz CJ Miller AB Reid RA Madauss KP Hassell A Hanlon MH Porter DJ Becherer JD Carter LH 《Bioorganic & medicinal chemistry letters》2008,18(15):4360-4363
We report the synthesis and in vitro activity of a series of novel pyrrolidinyl pyridones and pyrazinones as potent inhibitors of prolyl oligopeptidase (POP). Within this series, compound 39 was co-crystallized within the catalytic site of a human chimeric POP protein which provided a more detailed understanding of how these inhibitors interacted with the key residues within the catalytic pocket. 相似文献
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Newell AE Fiedler SE Ruan JM Pan J Wang PJ Deininger J Corless CL Carr DW 《Cell motility and the cytoskeleton》2008,65(7):539-552
A-kinase anchoring proteins (AKAPs) bind to protein kinase A (PKA) via an amphipathic helix domain that interacts with a dimerization/docking domain on the regulatory (R) subunit of PKA. Four other mammalian proteins (ROPN1, ASP, SP17, and CABYR) also contain a highly conserved RII dimerization/docking (R2D2) domain, suggesting all four proteins may interact with all AKAPs in a manner similar to RII. All four of these proteins were originally detected in the flagellum of mammalian sperm. In this report, we demonstrate that all four R2D2 proteins are expressed in a wide variety of tissues and three of the proteins SP17, CABYR, and ASP are located in motile cilia of human bronchus and fallopian tubes. In addition, we detect SP17 in primary cilia. We also provide evidence that ROPN1 and ASP bind to a variety of AKAPs and this interaction can be disrupted with anchoring inhibitor peptides. The interaction of SP17 and CABYR with AKAPs appears to be much more limited. None of the R2D2 proteins appears to bind cAMP, a fundamental characteristic of the regulatory subunits of PKA. These observations suggest that R2D2 proteins utilize docking interactions with AKAPs to accomplish their function of regulating cilia and flagella. Based on location, affinity for AKAPs and lack of affinity for cAMP, it appears that each R2D2 protein has a unique role in this process. 相似文献
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O. A. Gutierrez M. J. Wubben M. Howard B. Roberts E. Hanlon J. R. Wilkinson 《Russian Journal of Plant Physiology》2009,56(1):1-5
The phytohormones ethylene and auxin regulate many important processes in plants, including cell differentiation, cell expansion,
and responses to abiotic stresses. These hormones also play important roles in many plant-pathogen interactions, including
regulation of plant defense responses and symptom development. Sedentary plant-parasitic nematodes, which require the formation
of a complex feeding site within the host root, are among the world’s most destructive plant pathogens. Nematode-induced feeding
sites show dramatic changes in host cell morphology and gene expression. These changes are likely mediated, at least in part,
by phytohormones. In the present review, current knowledge of the roles of ethylene and auxin will be explored in two main
areas: the specific role of phytohormones in mediating feeding site development by plant-parasitic nematodes and the general
role of phytohormones in affecting the ability of parasitic nematodes to cause disease.
Published in Russian in Fiziologiya Rastenii, 2009, Vol. 56, No. 1, pp. 3–7.
This article was presented in original. 相似文献
50.
Olmos G Boyle L Horan B Berry DP O'Connor P Mee JF Hanlon A 《Animal : an international journal of animal bioscience》2009,3(1):96-107
The aim of the present study was to determine the effect of the genetic group of the Holstein-Friesian (HF) and pasture-based feeding system (3 × 2 factorial arrangement) on locomotion score (six gait aspects scored from one to five), clinical lameness and hoof disorders within a seasonal calving milk production system. The three genetic groups compared had an average Economic Breeding Index (EBI) value of 40, 70 and 80: representing the Irish national average genetic merit (LOW-NA), high EBI genetic merit of North American ancestry (HIGH-NA) and high EBI genetic merit of New Zealand ancestry (HIGH-NZ), respectively. Two feed systems were compared: a high grass allowance, low-concentrate system typical of spring-calving herds in Ireland (control) and a high-concentrate system. Data from 126 cows collected across a complete lactation period were analysed using generalised estimating equations and survival analysis. Genetic group of HF had a significant effect on locomotion score, clinical lameness and hoof disorders. Higher EBI cows (HIGH-NA and HIGH-NZ) had lower hazard of poor locomotion score in some gait aspects (e.g. spine curvature) and lower odds of clinical lameness in the first 200 days post-calving (Odds ratios 0.08 and 0.24, respectively, relative to the LOW-NA) and some hoof disorders (e.g. traumatic lesions) compared with LOW-NA cows. The high-concentrate feed system showed a higher incidence and severity of digital dermatitis (P < 0.01). Thus, high EBI cows have better locomotion, fewer cases of clinical lameness and less-severe hoof disorders (i.e. digital dermatitis, white line disease and traumatic lesions) than low EBI cows. These findings have important implications for cow welfare and productivity. 相似文献